کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3329663 1212410 2009 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimal timing for adjuvant radiation therapy in breast cancer: A comprehensive review and perspectives
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Optimal timing for adjuvant radiation therapy in breast cancer: A comprehensive review and perspectives
چکیده انگلیسی

PurposeThe optimal sequence of modalities involved in breast cancer treatment with respect to radiotherapy and the maximum acceptable interval between radiotherapy and surgery need to be determined.DesignThis review attempts a critical reading of the literature.ResultsA delay of radiotherapy more than 8–12 weeks after surgery adversely affects local recurrence. Radiotherapy should be administered within 7 months after surgery, when chemotherapy is administered first. Several chemotherapy regimens can be safely administered concurrently with radiotherapy. The concurrent use of tamoxifen with chemotherapy should be avoided, but not with radiotherapy. Data is insufficient with regard to concurrent use of aromatase inhibitors with radiotherapy. The use of trastuzumab concomitantly with radiotherapy may enhance toxicities but may also improve its efficacy.ConclusionsAlthough the issue of radiotherapy delay and that of sequence with chemotherapy or tamoxifen are clarified, the sequence of radiotherapy with aromatase inhibitors and trastuzumab needs to be defined. Individual radiosensitivity may influence toxicity. New biologic markers have to be determined in the future for tailoring radiotherapy in breast cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 71, Issue 2, August 2009, Pages 102–116
نویسندگان
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