کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3329674 1590723 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Concomitant chemo-radiotherapy in clinical trials: To promote step by step rational development
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Concomitant chemo-radiotherapy in clinical trials: To promote step by step rational development
چکیده انگلیسی

Based on previous reports and events, we attempted to demonstrate how to achieve sound, reliable clinical development, particularly in this new area where the oncologist will be faced with the dilemma of choosing the most appropriate chemo-radiotherapy combination for use in routine clinical practice in the near future. Data were obtained by searches of MEDLINE, PubMed, and references from relevant English-language articles. Among the different strategies aimed at improving therapy, drug–radiation combinations have the strongest impact on current solid tumor treatment practice. However, developing a new strategy combining RT and drugs without preclinical development and sufficiently solid data is prohibited. Preclinical phase should be considered a prerequisite for optimizing the success of the clinical phases in the interest of patients, oncologists and also of pharmaceutical companies, thereby avoiding pointless and sometimes expensive toxic trials. A caveat is directed at radiation oncologists, at the expense of scientific reliability and validity which surely, should not be compromised.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 70, Issue 3, June 2009, Pages 206–215
نویسندگان
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