کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3330112 1212432 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Negligible influence of comorbidity on prognosis of patients with small cell lung cancer: A population-based study in the Netherlands
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Negligible influence of comorbidity on prognosis of patients with small cell lung cancer: A population-based study in the Netherlands
چکیده انگلیسی

Management of small cell lung cancer (SCLC) among elderly is complex because of decreased organ functions and interactions with comorbidity. Since elderly patients are often excluded from clinical trials, little is known about the way they are treated and outcome.We evaluated the prognostic effects of rising age and comorbidity in unselected Dutch SCLC patients (Eindhoven Cancer Registry).Elderly patients received chemotherapy less often and the dose was also reduced more often. Cardiovascular diseases, hypertension or diabetes lowered the proportion receiving combined chemotherapy and radiotherapy among patients with limited disease. About 80% of the patients receiving chemotherapy suffered from a side effect, which was not related to age. After adjustment for age, gender, stage and treatment modality, comorbidity had a negligible prognostic effect. Chemotherapy (in combination with radiotherapy) seemed to improve survival, however, toxicity and quality of life in these patients should be evaluated thoroughly in future randomized studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 62, Issue 2, May 2007, Pages 172–178
نویسندگان
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