کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3331716 1590858 2010 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydroxyurea for Children with Sickle Cell Disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Hydroxyurea for Children with Sickle Cell Disease
چکیده انگلیسی

Hydroxyurea therapy offers promise for ameliorating the clinical course of children with sickle cell disease (SCD). Hydroxyurea is a prototypic therapeutic option; it can be administered with minimal side effects, has a relatively wide therapeutic window, and has mechanisms of action that address pathophysiologic pathways of sickling, vaso-occlusion, hemolysis, and organ damage. There are limited data regarding hydroxyurea's ability to prevent or diminish organ dysfunction, and the long-term risks of hydroxyurea therapy remain incompletely defined. Although clinical trials are underway to address long-term issues, hydroxyurea remains an effective but underutilized therapy for SCD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hematology/Oncology Clinics of North America - Volume 24, Issue 1, February 2010, Pages 199–214
نویسندگان
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