کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3331884 1590860 2009 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of Minimal Residual Disease Monitoring in Adult and Pediatric Acute Lymphoblastic Leukemia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Role of Minimal Residual Disease Monitoring in Adult and Pediatric Acute Lymphoblastic Leukemia
چکیده انگلیسی

Assays that measure minimal residual disease (MRD) can determine the response to treatment in patients with acute lymphoblastic leukemia (ALL) much more precisely than morphologic screening of bone marrow smears. The clinical significance of MRD, detected by flow cytometry or polymerase chain reaction-based methods in childhood ALL, has been established. Hence, MRD is being used in several clinical trials to adjust treatment intensity. Similar findings have been gathered in adult patients with ALL, making MRD one of the most powerful and informative parameters to guide clinical management. This article discusses practical issues related to MRD methodologies and the evidence supporting the use of MRD for risk assignment in clinical trials.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hematology/Oncology Clinics of North America - Volume 23, Issue 5, October 2009, Pages 1083–1098
نویسندگان
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