کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3332452 1213088 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hormonal contraceptive use and response to antiretroviral therapy among adolescent females
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Hormonal contraceptive use and response to antiretroviral therapy among adolescent females
چکیده انگلیسی

BackgroundTo assess hormonal contraceptive use and response to antiretroviral therapy (ART) as measured by changes in HIV-1 RNA viral load (VL) and CD4+ cell counts in HIV positive female adolescents on ART.Material and MethodsThis study used prospective longitudinal data from the REACH cohort to compare the response to ART in adolescent females using hormonal contraception to the response to ART in adolescent females not using hormonal contraception. Outcome measures were VL and CD4+ T cell counts assessed every 3 months. The association between hormonal contraception exposure and the response to ART was assessed using repeated measures multivariate analysis while adjusting for additional covariates.ResultsThe majority of participants were African American (73%). Median baseline age was 17 years (IQR 16 – 18). VL of ART users decreased over time in both hormonal contraception users (−0.0152 log copies/ml per day) and non-users (−0.0154 log copies/ml per day). However, the decrease was slightly lower (1.2 × 10−3, 95%CI: 6.2 × 10−5–2.4 × 10−3 copies/ml log VL per day, p-value = 0.03) among hormonal contraceptive users.ConclusionsThis study shows a significant association between hormonal contraception use and a diminished response to ART. However, the impact of hormonal contraception on HIV-1 acquisition, progression, and treatment is still not clear.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: HIV & AIDS Review - Volume 10, Issue 3, September 2011, Pages 65–69
نویسندگان
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