کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3334886 1213510 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biochemistry of storage lesions of red cell and platelet concentrates: A continuous fight implying oxidative/nitrosative/phosphorylative stress and signaling
ترجمه فارسی عنوان
بیوشیمی از ضایعات ذخیره سازی کنسانتره های گلبول قرمز و پلاکت: یک مبارزه مداوم است که مستلزم استرس اکسید کننده / نیتروژن / فسفرولیتر و سیگنالینگ
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی

The mechanisms responsible for the reduced lifespan of transfused red blood cells (RBCs) and platelets (PLTs) are still under investigation, however one explanation refers to the detrimental biochemical changes occurring during ex vivo storage of these blood products. A myriad of historical and more recent studies has contributed to advance our understanding of storage lesion. Without any doubts, proteomics had great impact on transfusion medicine by profiling the storage-dependent changes in the total detectable protein pool of both RBCs and PLTs. This review article focuses on the role of oxidative/nitrosative stress in developing RBC and PLT storage lesions, with a special glance at its biochemistry and cross-talk with phosphorylative signal transduction. In this sense, we enlighten the potential contribution of new branches of proteomics in identifying novel points of intervention for the improvement of blood product quality.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transfusion and Apheresis Science - Volume 52, Issue 3, June 2015, Pages 262–269
نویسندگان
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