کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3335001 1213518 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro properties of apheresis platelet during extended storage in plasma treated with anandamide
ترجمه فارسی عنوان
پلاکت های فائرز در شرایط آزمایشگاهی در طول ذخیره سازی طولانی در پلاسمای درمان شده با آناندامید
کلمات کلیدی
اناندامید، ذخیره سازی گسترده، ضایعات ذخیره سازی پلاکت
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی

BackgroundIn China apheresis platelets (PLTs) are stored in plasma for only 5 days, resulting in PLT inventory pressures. Anandamide (ANA) was reported to be a potential agent to inhibit PLT apoptosis. The aim of this study was to evaluate the characteristics of extended storage PLTs in plasma treated with ANA in vitro.MethodsApheresis PLTs (n = 20) were prepared in plasma treated with ANA, and stored at 22 °C for up to 11 days. On day 1, 3, 5, 7, 9 and 11, PLTs were tested for PLT count, mean PLT volume (MPV), PLT distribution width (PDW), pH, pCO2, pO2, hypotonic shock response (HSR), phosphatidylserine (PS) exposure and soluble P-selectin content.ResultsPLTs stored in plasma with/without ANA didn't show significant differences during the first 5 days of storage. From the 7th day on, PLTs stored in plasma with ANA displayed significantly lower PS expression, soluble P-selectin content and higher HSR scores than those stored in plasma without ANA (P < 0.05), respectively.ConclusionThe extended storage of PLTs in plasma treated with 0.5 µmol/l ANA showed better characteristics of the PLTs, compared with the control group, which was suggested to potentially alleviate the PLT storage lesion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transfusion and Apheresis Science - Volume 51, Issue 1, August 2014, Pages 58–64
نویسندگان
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