A positive effect of immune suppression on corrected count increment after platelet transfusion at 1 but not at 24Â h

The effects of patient characteristics on corrected count increment (CCI) in hemato-oncology patients were studied. CCI values were 13.6 ± 6.5 (1 h, n = 79) and 6.3 ± 5.3 (24 h, n = 69). With concomitant immune suppression CCI was higher at 1 h (20.0 ± 7.9 versus 13.2 ± 6.3, p = 0.023), but not at 24 h (5.9 ± 6.7 versus 6.3 ± 5.2; p = 0.88). The observed effect is short lived, potentially benefiting bleeding patients, but may not increase intervals between transfusions. Further, CCI1h was lower if fever was present (9.7 ± 3.6 versus 14.3 ± 6.7; p = 0.002), and corresponding CCI24h values were 3.7 ± 6.3 versus 6.7 ± 5.0 (p = 0.09). At 24 h an effect for previous transfusions was observed, 6.7 ± 5.1 (with) versus 1.6 ± 5.4 (without p = 0.02).