کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3335602 1213536 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A case of acquired dysfibrinogenemia in multiple myeloma treated with therapeutic plasma exchange
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
A case of acquired dysfibrinogenemia in multiple myeloma treated with therapeutic plasma exchange
چکیده انگلیسی

A 70 year old Caucasian woman with IgG lamda multiple myeloma presented with uncontrollable bleeding from a bone marrow biopsy site which started days after the procedure. The patient was hyperviscous, and coagulation tests showed elevated activated partial thromboplastin time (aPTT) which was not corrected with a mixing study, elevated thrombin time and reptilase time, and possible inhibitors to Factors VIII and IX. Therapeutic plasma exchange was performed using plasma with corrections of plasma viscosity (1.6 to 1.1 centipoise) and aPTT (50 to 42.1 s) observed. The bleeding was controlled, and purified IgG demonstrated dysfibrinogenemic effects of the patient’s paraprotein.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transfusion and Apheresis Science - Volume 48, Issue 1, February 2013, Pages 35–38
نویسندگان
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