کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3335752 1213542 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
The cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia
چکیده انگلیسی

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal antibodies that cross the placenta in connection with pregnancy and destroy fetal platelets. Recently, maternal T cell responses associated with FNAIT have been studied at the clonal level. These T cell clones recognize an integrin β3 epitope, which is anchored to the HLA-DRB3∗0101-encoded MHC molecule DR52a. The same MHC allele is strongly associated with FNAIT. As the production of pathological antibodies reactive with fetal platelets is likely dependent on these T cell responses, there exists a potential for preventing FNAIT by targeting these T cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transfusion and Apheresis Science - Volume 45, Issue 1, August 2011, Pages 53–59
نویسندگان
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