کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3335962 1213552 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Factors affecting hematopoietic progenitor cell mobilization: An analysis of 307 patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Factors affecting hematopoietic progenitor cell mobilization: An analysis of 307 patients
چکیده انگلیسی

We reviewed the data of 307 patients treated with autologous bone marrow transplantation with the aim to identify factors associated with poor hematopoietic stem cell (HSC) mobilization after administration of cyclophosphamide and granulocyte-colony stimulating factor. Success in mobilization was defined when ⩾ 2.0 × 106 CD34+ cells/kg weight could be collected with ⩽ 3 leukapheresis procedures. Success was observed in 260 patients (84.7%) and nonsuccess in 47 patients (15.3%). According to the stepwise regression model: diagnosis, chemotherapy load, treatment with mitoxantrone and platelet count before mobilization were found to be independent predictive factors for HSC mobilization. These results could help in the previous recognition of patients at risk for non response to mobilization and allow to plan an alternative protocol for this group of patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transfusion and Apheresis Science - Volume 39, Issue 3, December 2008, Pages 187–192
نویسندگان
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