Anti-KEL7 (anti-Jsb) alloimmunization diagnostic supported by molecular KEL∗6,7 typing in a pregnant woman with previous intrauterine deaths

Anti-KEL7 (anti-Jsb) is a rare antibody that has been related to haemolytic transfusion reactions and HDN. We report a case of anti-KEL7 alloimmunization detected in a pregnant woman who had an obstetric previous history of four miscarriages and one stillborn. Employing classical immunohematological techniques, we studied the propositus and her available relatives. Due to the unavailability of commercial anti-KEL6 and anti-KEL7 reagents, we used a KEL∗6,7 genotyping method as an alternative tool to contribute with the identification of the alloantibody origin. The results of KEL genotyping showed that the propositus was KEL∗6/6 homozygous, while her second partner was KEL∗7/7 homozygous.