کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3336958 1213640 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transfusion-Transmitted Cytomegalovirus: Lessons From a Murine Model
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Transfusion-Transmitted Cytomegalovirus: Lessons From a Murine Model
چکیده انگلیسی

Transfusion-transmitted cytomegalovirus (CMV) infection (TT-CMV) continues to complicate blood transfusion therapy, which can lead to severe morbidity or mortality in immunocompromised or immuno-immature recipients. The biological mechanisms that underlie TT-CMV (eg, viral latency in donor monocytes or stimulatory signals in the transfusion recipient leading to cytomegalovirus reactivation) are difficult to study in humans, but can be addressed in animal models. In this review, we discuss a mouse blood transfusion model, which can be used to investigate these issues as well as to validate methods to prevent TT-CMV in at-risk patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transfusion Medicine Reviews - Volume 21, Issue 1, January 2007, Pages 26–36
نویسندگان
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