کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
333942 545994 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Decreased recognition of negative affect after selective serotonin reuptake inhibition is dependent on genotype
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Decreased recognition of negative affect after selective serotonin reuptake inhibition is dependent on genotype
چکیده انگلیسی

Selective serotonin reuptake inhibitors (SSRIs) are known to influence the information processing of emotional material in depressed patients and healthy controls. The functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) has been shown to interact with the effectiveness of serotonin reuptake inhibitors. It is not known whether 5-HTTLPR has an influence on emotional processing in healthy controls. We report first data with long-term SSRI administration after genetic characterization of 5-HTTLPR in a randomized, double-blind, placebo-controlled, crossover design. In 30 healthy controls, 15 homozygous for the long and 15 for the short allele of 5-HTTLPR, emotionally valent images were used to elicit positive or negative emotions. We found a diminished perception of sad and fearful information under SSRI which was significant in the long allele group. These findings emphasize the importance of genetic variance in emotion processing research.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 177, Issue 3, 30 May 2010, Pages 354–357
نویسندگان
, , , , , , , ,