کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3341437 1214211 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pulmonary artery aneurysms in Behçet's disease treated with anti-TNFα: A case series and review of the literature
ترجمه فارسی عنوان
آنوریسم شریان ریوی در بیماری بهجت با درمان ضد TNFα: یک سری موارد و بررسی ادبیات
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی

Behçet's disease (BD) is a systemic inflammatory disorder of unknown aetiology. Pulmonary haemorrhage from ruptured pulmonary artery aneurysms (PAA) in this condition carries a high mortality but treatment has largely been empiric with use of glucocorticoids and cyclophosphamide. Tumour necrosis factor α (TNF-α) was recently recognised as a mediator in the pathogenesis of BD inflammatory lesions. TNFα inhibitors have been shown in various case reports/series to have beneficial effects in uveoretinitis, entero-Behçet's, neuro-Behçet's and BD arthritis. We describe the efficacy and tolerability of infliximab in 2 patients with Behçet's disease complicated by pulmonary vasculitis admitted to our unit during the years 2004–2015, and discuss the previously published data in this area.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 15, Issue 4, April 2016, Pages 375–378
نویسندگان
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