کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3341492 1214216 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The critical role of toll-like receptors — From microbial recognition to autoimmunity: A comprehensive review
ترجمه فارسی عنوان
نقش حیاتی گیرنده های عوارض مانند از شناخت میکروبی به سیستم ایمنی بدن: یک بررسی جامع
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی

Toll-like receptors (TLRs) constitute an important mechanism in the activation of innate immune cells including monocytes, macrophages and dendritic cells. Macrophage activation by TLRs is pivotal in the initiation of the rapid expression of pro-inflammatory cytokines TNF, IL-1β and IL-6 while promoting Th17 responses, all of which play critical roles in autoimmunity. Surprisingly, in inflammatory arthritis, activation of specific TLRs can not only induce but also inhibit cellular processes associated with bone destruction. The intercellular and intracellular orchestration of signals from different TLRs, their endogenous or microbial ligands and accessory molecules determine the activating or inhibitory responses. Herein, we review the TLR-mediated activation of innate immune cells in their activation and differentiation to osteoclasts and the capacity of these signals to contribute to bone destruction in arthritis. Detailed understanding of the opposing mechanisms of TLRs in the induction and suppression of cellular processes in arthritis may pave the way to develop novel therapies to treat autoimmunity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 15, Issue 1, January 2016, Pages 1–8
نویسندگان
, , ,