کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3342263 1214274 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-topoisomerase I autoantibodies in systemic sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Anti-topoisomerase I autoantibodies in systemic sclerosis
چکیده انگلیسی

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin, vascular abnormalities and activation of the immune system. The majority of SSc patients have autoantibodies against nuclear antigens. Among these antibodies against topoisomerase I (topo I) are frequently detected in sera of SSc patients. Since the discovery of these antibodies as immunoglobulins reacting with a 70 kDa nuclear protein (Scl-70), a massive body of clinical and experimental data has been generated. In this review we summarize accumulated evidence about anti-topo I autoantibodies in SSc, including results of epitope mapping studies and investigations on the possible pathogenic role of these antibodies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 8, Issue 8, July 2009, Pages 692–696
نویسندگان
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