کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3342416 1214285 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SAP discovery : The sword edges — Beneficial and harmful
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
SAP discovery : The sword edges — Beneficial and harmful
چکیده انگلیسی

We cloned the SLAM associated protein (SAP) gene in 1995. In 1998, it was discovered that the SAP gene was defective in patients with X-linked lymphoproliferative disease. Subsequently, details on the key role of life-long immune memory (vaccination) and of life-long autoantibody production in patients suffering from autoimmune disease have been revealed. In this paper, we discuss the dual nature of SAP in humans: its beneficial effect on life-long immune memory (vaccination) and its harmful effect on life-long autoantibody production.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 6, Issue 7, August 2007, Pages 444–449
نویسندگان
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