کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
334592 | 546596 | 2010 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Regional increase in P-glycoprotein function in the blood-brain barrier of patients with chronic schizophrenia:: A PET study with [11C]verapamil as a probe for P-glycoprotein function Regional increase in P-glycoprotein function in the blood-brain barrier of patients with chronic schizophrenia:: A PET study with [11C]verapamil as a probe for P-glycoprotein function](/preview/png/334592.png)
P-glycoprotein (P-gp), a major efflux pump in the blood-brain barrier (BBB) has a profound effect on entry of drugs, peptides and other substances into the central nervous system (CNS). The brain's permeability can be negatively influenced by modulation of the transport function of P-gp. Inflammatory mediators play a role in schizophrenia, and may be able to influence the integrity of the BBB, via P-gp modulation. We hypothesized that P-gp function in the BBB is changed in patients with schizophrenia. Positron-emission tomography was used to measure brain uptake of [11C]verapamil, which is normally extruded from the brain by P-gp. We found that patients with chronic schizophrenia under treatment with antipsychotic drugs compared with healthy controls showed a significant decrease in [11C]verapamil uptake in the temporal cortex, the basal ganglia, and the amygdala, and amygdalae, and a trend towards a significant decrease was seen throughout the brain. The decrease of [11C]verapamil uptake correlates with an increased activity of the P-gp pump. Increased P-gp activity may be a factor in drug resistance in schizophrenia, induced by the use of antipsychotic agents.
Journal: Psychiatry Research: Neuroimaging - Volume 183, Issue 2, 30 August 2010, Pages 151–156