Genetic diversity of genes encoding OKP and LEN β-lactamases produced by clinical Klebsiella pneumoniae strains in Portugal

Of the 308 clinical Klebsiella pneumoniae strains collected in 21 Portuguese health institutions, 11 encoded for LEN and 9 for OKP enzymes; of these, 15 were new enzymes. Ninety-one percent of LEN and all OKP producer strains were resistant to amoxicillin. We demonstrate that these β-lactamase were highly diverse.