کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
335121 546785 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Grey matter volume reductions in the emotion network of patients with depression and coronary artery disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Grey matter volume reductions in the emotion network of patients with depression and coronary artery disease
چکیده انگلیسی

Coronary Artery Disease (CAD) and Major Depressive Disorder (MDD) commonly co-occur and may be linked by a network of brain regions involved in emotion regulation, including the orbitofrontal cortex, amygdala/parahippocamal region and insula. We hypothesized structural differences in this emotion network more prominently in CAD + MDD versus CAD and healthy control (CTRL) groups that do not involve depression-related emotion circuitry. In contrast, we hypothesized structural similarities between CAD + MDD and MDD groups, both involving depression-related circuitry. We obtained structural magnetic resonance imaging scans from age-matched consenting subjects (CAD + MDD, n = 12; CAD, n = 12; MDD, n = 19; CTRL, n = 17) and performed a region of interest analysis. We found decreased grey matter volumes in the bilateral orbitofrontal cortex, bilateral amygdala/parahippocampal gyrus and right insula in CAD + MDD versus CTRL subjects and decreased grey matter volumes in the bilateral amygdala/parahippocampal regions in CAD + MDD versus CAD subjects. We found grey matter reductions in the right orbitofrontal cortex of CAD + MDD versus MDD subjects, and reductions in right insula of CAD versus CRTL subjects. Our results support that the network of brain regions involved in emotion regulation may be relevant to the relationship between CAD and MDD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 181, Issue 1, 30 January 2010, Pages 9–14
نویسندگان
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