کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3363663 1592124 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Incidence of childhood Haemophilus influenzae type b meningitis in Sri Lanka
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Incidence of childhood Haemophilus influenzae type b meningitis in Sri Lanka
چکیده انگلیسی

ObjectiveTo demonstrate the burden of Haemophilus influenzae type b (Hib) disease in Sri Lanka and provide information for decision-making in public health planning and vaccine introduction.MethodsThis was a prospective, population-based study carried out in 2004, to describe the epidemiology and calculate the incidence of meningitis caused by Hib in children <5 years of age in the district of Colombo, Sri Lanka. Hib was identified in cerebrospinal fluid (CSF) specimens by culture and antigen detection (latex agglutination test; LAT).ResultsThe lumbar puncture rate in children <5 years of age was 1.9%. A causative bacterial organism was identified in 108 meningitis cases, and in 54 (50%) this was Hib. The LAT increased the Hib detection rate in CSF four-fold. In 2004, the annual incidence of Hib meningitis in Colombo was 20.1 cases per 100 000 children aged <5 years.ConclusionsThis study is the first from Sri Lanka reporting the Hib meningitis incidence rate pre-vaccine introduction. The reported incidence rate is one of the highest from the Asian region, but is likely an underestimation considering the difficulties in the laboratory identification of Hib.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Infectious Diseases - Volume 14, Issue 5, May 2010, Pages e372–e376
نویسندگان
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