کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3364685 1592136 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The safety and immunogenicity of influenza vaccine in children with asthma in Mexico
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
The safety and immunogenicity of influenza vaccine in children with asthma in Mexico
چکیده انگلیسی

SummaryBackgroundThe morbidity and mortality associated with influenza is substantial in children with asthma. There are no available data on the safety and immunogenicity of influenza vaccine in children with asthma in Latin America. Furthermore, it is unclear if influenza vaccination may cause asthma exacerbations.MethodsWe conducted a placebo-controlled trial to investigate the safety and immunogenicity of an inactivated trivalent split virus influenza vaccine in children with asthma in Mexico. We also measured the impact of influenza vaccination on pulmonary function tests in this population.ResultsThe inactivated influenza vaccine was immunogenic and safe in terms of local and systemic side effects compared to placebo. We observed no significant impact on pulmonary function tests among vaccine recipients.ConclusionsGiven the significant morbidity associated with influenza in children, strategies to promote increased influenza vaccination coverage in this high-risk group in Latin America and elsewhere are urgently needed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Infectious Diseases - Volume 13, Issue 4, July 2009, Pages 469–475
نویسندگان
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