کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3370314 1219071 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antibodies from patients with dengue viral infection mediate cellular cytotoxicity
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Antibodies from patients with dengue viral infection mediate cellular cytotoxicity
چکیده انگلیسی

SummaryAcute and late convalescent sera (collected at day 5 of disease onset and 1 year later) from dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) laboratory confirmed cases, were tested for antibody-dependent cell-mediated cytotoxicity (ADCC) activity using dengue 1 (DENV-1) or dengue 2 (DENV-2) infected cells as target. All patients experienced their first dengue virus (DENV) infection 20 years before. ADCC activity was detected in acute sera from DHF/DSS but not in sera from DF patients. However, 1 year after illness, ADCC activity was observed in all cases. This preliminary report represents one of the few studies of ADCC in dengue patients and suggests that ADCC could be implicated in dengue pathogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Virology - Volume 37, Issue 1, September 2006, Pages 53–57
نویسندگان
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