کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3370902 1219095 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An increasing incidence of chickenpox central nervous system complications in children: What's happening in Tuscany?
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
An increasing incidence of chickenpox central nervous system complications in children: What's happening in Tuscany?
چکیده انگلیسی

BackgroundThe most frequent noncutaneous site of involvement of chickenpox is the central nervous system (CNS) and complications include cerebellar ataxia, encephalitis, and meningitis.ObjectivesWe have recently observed an unusually high number of children with chickenpox CNS complications in our university children's hospital. A study to evaluate the incidence of these complications over time in children living in Tuscany was carried out.Study designWe evaluated all cases of chickenpox and chickenpox complications leading to hospitalization in children aged 1 month–14 years reported to the Tuscany public health centre between 1997 and 2004. The International Classification of Disease Ninth Revision-CM hospital discharge diagnostic codes and medical records were used.ResultsThe incidence (95% confidence interval) of CNS complications/1000 chickenpox cases was stable between 1997 and 2001 [1997: 0.80 (0.29–1.74); 1998: 0.73 (0.29–1.50); 1999: 0.67 (0.25–1.46); 2000: 0.56 (0.15–1.44); 2001: 0.59 (0.16–1.50)] but increased significantly (χ2 for trend: 9.401; p = .0021) in 2002 [1.56 (0.83–2.66)], in 2003 [1.73 (0.95–2.90)] and in 2004 [1.51 (0.74–2.27)]. Non-CNS complications remained stable over time.ConclusionsPossible factors biasing the result were taken into account. Reasons of increased CNS complications remain unknown, but the possible emergence of a particularly neurotropic strain of varicella-zoster virus should be further investigated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Virology - Volume 38, Issue 4, April 2007, Pages 358–361
نویسندگان
, , , ,