کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3374427 | 1219618 | 2014 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The E genotype of hepatitis B: Clinical and virological characteristics, and response to interferon The E genotype of hepatitis B: Clinical and virological characteristics, and response to interferon](/preview/png/3374427.png)
SummaryObjectives10 hepatitis B virus (HBV) genotypes are known with different geographic distribution and response to interferon (IFN) therapy. The E genotype is the more prevalent genotype in West and Central Africa, but few data about response to IFN are available.We describe the epidemiological and clinical characteristics in a cohort of patients immigrants from Africa in our country with HBV E genotype chronic hepatitis infection (CHB).Methods63 patients with CHB and E genotype were included; 41 with CHB and low viral load were treated with PEG-IFN monotherapy; 10 with CHB and high viral load with sequential approach (entecavir and PEG-IFN). 12 patients with inactive CHB were followed with blood sample and abdomen ultrasonography every six months.ResultsThe virological response in the monotherapy group was 17.9%. Hepatitis B surface antigen (HBsAg) loss was observed in 1 patient (2.5%); 56 patients (88%) showed at the time of diagnosis of CHB another infectious diseases that required specific treatment before PEG-IFN; this treatment was also affected by an higher incidence of side-effects (>50%). All patients with high viremia showed a primary non-response to PEG-IFN.ConclusionsThe HBV E genotype evidences the worse response to PEG-IFN and maybe requires novel treatment options.
Journal: Journal of Infection - Volume 69, Issue 1, July 2014, Pages 81–87