کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3375980 1219703 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Daptomycin in the treatment of vancomycin-resistant Enterococcus faecium bacteremia in neutropenic patients
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Daptomycin in the treatment of vancomycin-resistant Enterococcus faecium bacteremia in neutropenic patients
چکیده انگلیسی

SummaryObjectiveVancomycin resistant enterococcal (VRE) blood stream infection (BSI) in neutropenic patients is associated with poor outcome. We report our experience in treating VRE BSI in febrile, neutropenic patients with daptomycin, a recently licensed lipopeptide with bactericidal activity against VRE.Patients and methodsPatients with fever, neutropenia and VRE BSI were treated with more than one dose of daptomycin (either 6 mg/kg/day or 4 mg/kg/day) in an open label, emergency-use trial. Patients were then assessed for clinical and microbiological cures and survival. MIC's of isolates to daptomycin were determined.ResultsNine febrile, neutropenic patients with VRE BSI received daptomycin. Four of 9 courses (44%) had clinical and/or microbiologic cure. Two of the 5 who failed cure died within 3 days of initiation of daptomycin. Five subjects survived to 30 days after the onset of BSI.ConclusionsUse of daptomycin in neutropenic patients with VRE BSI deserves further study as a treatment for VRE BSI in neutropenic patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection - Volume 54, Issue 6, June 2007, Pages 567–571
نویسندگان
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