کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3375981 1219703 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fibrinogen-beta gene haplotype is associated with mortality in sepsis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Fibrinogen-beta gene haplotype is associated with mortality in sepsis
چکیده انگلیسی

SummaryObjectivesFibrinogen plays a key role in coagulation and inflammation. Transcription of the fibrinogen-beta gene (FGB) is the rate-limiting step in fibrinogen production. Our aim was to determine whether haplotypes of FGB are associated with mortality and organ dysfunction in a cohort of patients with sepsis.MethodsA prospective cohort of 631 consecutive Caucasian patients with sepsis from a tertiary care medical–surgical ICU were enrolled in a gene association study. Patients were genotyped for three polymorphisms in FGB: −854 G/A, −455 G/A, and +9006 G/A. Haplotypes were inferred using PHASE. The primary outcome was mortality. Secondary outcomes were severity of organ dysfunction as measured by days alive and free (DAF) of organ dysfunction.ResultsHaplotype GAA was associated with a significantly lower 28-day mortality (28.9% vs. 36.9% for all other haplotypes, p = 0.03). Carriers of two copies of haplotype GAA (vs. one and zero copies) had more DAF of organ dysfunction. In a multivariate analysis, haplotype GAA was an independent predictor for lower mortality (OR = 0.66, 95% CI = 0.46–0.94, p = 0.02).ConclusionsHaplotype GAA in FGB is associated with lower mortality and lower severity of organ dysfunction. Haplotype GAA encompasses a previously described haplotype −1420A/−854G/−455A/−249C/−148T/+1690G that is associated with higher fibrinogen levels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection - Volume 54, Issue 6, June 2007, Pages 572–577
نویسندگان
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