کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3376508 1219738 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human papillomavirus and circumcision: A meta-analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Human papillomavirus and circumcision: A meta-analysis
چکیده انگلیسی

SummaryBackgroundDetermine the relationship of circumcision status to the risk for genital infection with human papillomavirus (HPV).MethodsA MEDLINE search and a review of references in published articles were used to identify publications from peer-reviewed journals in Index Medicus with data on circumcision status in patients with and without HPV infections. Inclusion criteria included diagnosis by culture, biopsy, or PCR, determination of circumcision status by physical examination, and multiple site sampling including the shaft of the penis. A meta-analysis was performed with sensitivity analyses.ResultsSixteen articles contained data on circumcision status in patients with and without HPV infections. Eight studies used accurate diagnostic methods. Only three articles satisfied the strict inclusion criteria. There was no significant association between circumcision status and HPV infection (random-effects model summary effect OR = 1.20, 95%CI = 0.80–1.79) in these three studies. If the eight studies using accurate diagnostic methods are adjusted for the method of determining circumcision status and failure to sample the penile shaft using meta-regression the summary effects odds ratio is 1.25 (95%CI = 0.95–1.67).ConclusionsThe medical literature does not support the claim that circumcision reduces the risk for genital HPV infection. To correctly assess the risk of HPV infection in circumcised males, the penile shaft needs to be sampled for HPV infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection - Volume 54, Issue 5, May 2007, Pages 490–496
نویسندگان
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