کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3379681 1220173 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
OARSI Clinical Trials Recommendations: Design and conduct of clinical trials of surgical interventions for osteoarthritis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ایمونولوژی، آلرژی و روماتولوژی
پیش نمایش صفحه اول مقاله
OARSI Clinical Trials Recommendations: Design and conduct of clinical trials of surgical interventions for osteoarthritis
چکیده انگلیسی

SummaryTo highlight methodological challenges in the design and conduct of randomized trials of surgical interventions and to propose strategies for addressing these challenges. This paper focuses on three broad areas: enrollment; intervention; and assessment including implications for analysis. For each challenge raised in the paper, we propose potential solutions. Enrollment poses challenges in maintaining investigator equipoise, managing conflict of interest and anticipating that patient preferences for specific treatments may reduce enrollment. Intervention design and implementation pose challenges relating to obsolescence, fidelity of intervention delivery, and adherence and crossover. Assessment and analysis raise questions regarding blinding and clustering of observations. This paper describes methodological problems in the design and conduct of surgical randomized trials and proposes strategies for addressing these challenges.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Osteoarthritis and Cartilage - Volume 23, Issue 5, May 2015, Pages 798–802
نویسندگان
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