کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3381791 1220268 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Developmental failure of the intra-articular ligaments in mice with absence of growth differentiation factor 5
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ایمونولوژی، آلرژی و روماتولوژی
پیش نمایش صفحه اول مقاله
Developmental failure of the intra-articular ligaments in mice with absence of growth differentiation factor 5
چکیده انگلیسی

SummaryObjectiveTo show the phenotypic characteristics of the knee joints in brachypodism mice (bp mice), which carry a functional null mutation of the growth differentiation factor 5 (GDF5) gene, we investigated the adult and embryonic bp mice.MethodRadiographic and macroscopic examinations of the knee joint of adult bp mice were performed. A histological examination of the knee joint of bp mice from E12.5 to E18.5 was also performed.ResultsRadiographic and macroscopic examinations of the adult bp mice showed anterior dislocation, hypoplastic condyles, and absence of the intra-articular ligaments. Safranin O staining of knee joints of the embryonic bp mice showed severe hypoplasty of the chondroepiphyses and intra-articular ligaments at E16.5. There was no difference in the number and location of 5-bromo-2′-deoxyuridine (BrdU)-positive cells between wild-type and bp mice through E12.5 to E14.5. A terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL) study showed excessive cell death of mesenchymal cells of the future knee joint in bp mice at E12.5 and E13.5.Conclusionbp mice exhibit developmental failure of the condyles and intra-articular ligament of the knee joints.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Osteoarthritis and Cartilage - Volume 15, Issue 4, April 2007, Pages 468–474
نویسندگان
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