کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
338691 547976 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Course of illness in a sample of 265 patients with first-episode psychosis—Five-year follow-up of the Danish OPUS trial
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Course of illness in a sample of 265 patients with first-episode psychosis—Five-year follow-up of the Danish OPUS trial
چکیده انگلیسی

There is an ongoing debate as to whether psychosis is a progressively deteriorating illness or one of progressive amelioration. This paper aims at investigating the rate of recovery and institutionalization and predicting a continuous illness course in a descriptive prospective study of a sub-sample of the OPUS trial of 265 first-episode psychotic patients after five years.Recovery, defined as no psychotic or negative symptoms, living independently, GAF (f) > 59, working or studying, was reached for 18% after five years, whereas 13% were institutionalized either at hospital or supported housing after five years.Male gender (OR 1.9, 95% CI 1.06 to 3.23), premorbid social functioning (OR 1.2, 95% CI 1.01 to 1.33), psychotic symptoms (OR 1.3, 95% CI 1.07 to 1.66), and negative symptoms (OR 1.3, 95% CI 1.01 to 1.67) were found to predict a continuous illness course at five-year follow-up.Rates of recovery and institutionalization contradict the assumption that the illness deteriorates progressively, since no changes in the rates are seen from two to five years.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 107, Issues 2–3, February 2009, Pages 173–178
نویسندگان
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