کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
339216 548056 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Environmental factors and social adjustment as predictors of a first psychosis in subjects at ultra high risk
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Environmental factors and social adjustment as predictors of a first psychosis in subjects at ultra high risk
چکیده انگلیسی

BackgroundThe onset of schizophrenia is associated with genetic, symptomatic, social and environmental risk factors. The aim of the present study was to determine which environmental factors may contribute to a prediction of a first psychotic episode in subjects at Ultra High Risk (UHR) for developing psychosis.MethodWe included 72 UHR subjects and followed them over a period of 36 months, of whom nineteen (26.4%) made a transition to psychosis. We applied survival analyses to determine associations between a transition to psychosis and environmental factors and social adjustment. To determine which items are the best predictors of transition to a first psychotic episode, Cox Regression analyses were applied.ResultsUrbanicity, receiving state benefits and poor premorbid adjustment (PMA) significantly influenced the transition to psychosis. Urbanicity (Wald = 10.096, p = .001, HR = 30.97), social–sexual aspects (Wald = 8.795, p = .003, HR = 1.91) and social–personal adjustment (Wald = 10.794, p = .001, HR = 4.26) appeared to be predictors for developing psychosis in our UHR group.ConclusionsEnvironmental characteristics and social adjustment are predictive of transition to a psychosis in subjects at UHR. These characteristics should be implemented in a model for prediction of psychosis. Such a model would be more specific than current models and may lead to patient-specific preventive interventions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 125, Issue 1, January 2011, Pages 69–76
نویسندگان
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