کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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339216 | 548056 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Environmental factors and social adjustment as predictors of a first psychosis in subjects at ultra high risk Environmental factors and social adjustment as predictors of a first psychosis in subjects at ultra high risk](/preview/png/339216.png)
BackgroundThe onset of schizophrenia is associated with genetic, symptomatic, social and environmental risk factors. The aim of the present study was to determine which environmental factors may contribute to a prediction of a first psychotic episode in subjects at Ultra High Risk (UHR) for developing psychosis.MethodWe included 72 UHR subjects and followed them over a period of 36 months, of whom nineteen (26.4%) made a transition to psychosis. We applied survival analyses to determine associations between a transition to psychosis and environmental factors and social adjustment. To determine which items are the best predictors of transition to a first psychotic episode, Cox Regression analyses were applied.ResultsUrbanicity, receiving state benefits and poor premorbid adjustment (PMA) significantly influenced the transition to psychosis. Urbanicity (Wald = 10.096, p = .001, HR = 30.97), social–sexual aspects (Wald = 8.795, p = .003, HR = 1.91) and social–personal adjustment (Wald = 10.794, p = .001, HR = 4.26) appeared to be predictors for developing psychosis in our UHR group.ConclusionsEnvironmental characteristics and social adjustment are predictive of transition to a psychosis in subjects at UHR. These characteristics should be implemented in a model for prediction of psychosis. Such a model would be more specific than current models and may lead to patient-specific preventive interventions.
Journal: Schizophrenia Research - Volume 125, Issue 1, January 2011, Pages 69–76