In-vitro anti-inflammatory and mosquito larvicidal efficacy of nickel nanoparticles phytofabricated from aqueous leaf extracts of Aegle marmelos Correa

• Phytofabrication of nickel NPs by using Aegle marmelos Correa aqueous leaf extract.
• Triangle shape nickel NPs (80–100 nm) having face centered cubic structure.
• Steady weight loss in the temperature range of 100–800 °C.
• Nickel NPs of AMC with good in-vitro anti-inflammatory efficacy and comparable to that of standard Aceclofenac.
• Better larvicidal efficacy against Culex quinquefasciatus.

In recent years there is a tremendous growth in the interdisciplinary world of nanotechnology across the globe and emergence of its potential applications remains as a big revolution to the industry. Fusion of green nanotechnology and medicine represents one of the major breakthroughs of modern science with the aim of developing nanomaterials for diagnosis, treatment, prevention of various diseases and overall improving health for the beneficial of mankind. In the present study phytofabrication of nickel nanoparticles (nickel NPs) was carried out by using indigenous Aegle marmelos Correa aqueous leaf extracts as a reducing, stabilizing and capping agents. Nickel NPs were characterized by UV-spectroscopy, FTIR, XRD, SEM, AFM and TGA studies. Phytosynthesis of nickel NPs was monitored both at room temperature (25 °C) and at 60 °C for 5 h. The green synthesis of triangular shape nickel NPs phytofabricated from A. marmelos Correa aqueous leaf extracts having face centered cubic structure showing an average particle size of 80–100 nm which is in consistent with the particle size calculated by XRD Scherer equation. We further explored and compared nickel NPs of A. marmelos Correa with crude leaf extracts of A. marmelos Correa for its in-vitro anti-inflammatory and mosquito larvicidal efficacy against three blood feeding parasites. The results obtained clearly gives an idea that nickel NPs of A. marmelos Correa (NiNPs of AmC) possess an enhanced anti-inflammatory and larvicidal activity when compared to crude leaf extracts of A. marmelos Correa.

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