کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3393967 1592798 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research needs for Chagas disease prevention
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Research needs for Chagas disease prevention
چکیده انگلیسی

We present an overview of the two main strategies for the primary (vector control) and secondary (patient care) prevention of Chagas disease (CD). We identify major advances, knowledge gaps, and key research needs in both areas. Improved specific chemotherapy, including more practical formulations (e.g., paediatric) or combinations of existing drugs, and a better understanding of pathogenesis, including the relative weights of parasite and host genetic makeup, are clearly needed. Regarding CD vectors, we find that only about 10–20% of published papers on triatomines deal directly with disease control. We pinpoint the pitfalls of the current consensus on triatomine systematics, particularly within the Triatomini, and suggest how some straightforward sampling and analytical strategies would improve research on vector ecology, naturally leading to sounder control-surveillance schemes. We conclude that sustained research on CD prevention is still crucial. In the past, it provided not only the know-how, but also the critical mass of scientists needed to foster and consolidate CD prevention programmes; in the future, both patient care and long-term vector control would nonetheless benefit from more sharply focused, problem-oriented research.

We present an overview of the main strategies for the primary (vector control) and secondary (patient care) prevention of Chagas disease (CD), surveying research achievements and key needs.Pictogram shows the scientific production on triatomines and on triatomine control in three major bibliographic databases.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Tropica - Volume 115, Issues 1–2, July–August 2010, Pages 44–54
نویسندگان
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