کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3394140 | 1221447 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Low serum levels of cathelicidin LL-37 in leprosy Low serum levels of cathelicidin LL-37 in leprosy](/preview/png/3394140.png)
The antimicrobial peptide cathelicidin LL-37 possesses antituberculous activity, its association with other mycobacterial diseases, such as leprosy, is unknown. We studied serum cathelicidin and 25OH-vitamin D3 levels in 29 leprosy patients and 19 healthy individuals from Yemen. Cathelicidin levels were significantly lower in both treated (n = 15) and untreated leprosy patients (n = 14) when compared to controls (P < 0.001). Within leprosy patients, levels were lower in those who very recently developed disease (untreated group) when compared to already treated patients (P < 0.05). 25OH-vitamin D3 levels were not different between groups. The results suggest a potential association of cathelicidin LL-37 with Mycobacterium leprae infection.
Serum cathelicidin and 25OH-vitamin D3 levels were studied in 29 leprosy patients (both untreated and treated) and 19 healthy individuals from Yemen. Cathelicidin levels were significantly lower in leprosy patients. 25OH-vitamin D3 levels were not different between groups.Figure optionsDownload as PowerPoint slide
Journal: Acta Tropica - Volume 117, Issue 1, January 2011, Pages 56–59