کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3394229 | 1221454 | 2010 | 5 صفحه PDF | دانلود رایگان |

The effect of two water-soluble polymers: pectin and polyvinylpyrrolidone in combination with β-cyclodextrin, on the dissolution, bioavailability and cysticidal efficacy of albendazole was evaluated using a commercial suspension as reference product. The dissolution of the albendazole–β-cyclodextrin–pectin formulation was slow and incomplete (44.7%). No statistical differences in Cmax and AUC were found between this formulation and the reference. Also its cysticidal efficacy (33%) was similar to the reference (38%). The albendazole–β-cyclodextrin–polyvinylpyrrolidone formulation exhibited the highest dissolution rate (78.5%) and its bioavailability was also significantly increased (2.3-fold). In addition, the cysticidal activity of this formulation (83%) was greater than a commercial suspension. Our results suggest that the ternary system of albendazole–β-cyclodextrin–polyvinylpyrrolidone could be a potential alternative for the treatment of systemic helmintic diseases and it is worth to continue its preclinical evaluation.
Journal: Acta Tropica - Volume 113, Issue 1, January 2010, Pages 56–60