کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3394683 1592801 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Concomitant pleural and disseminated tuberculosis in Aids: Immune response or HIV infection compartmentalization?
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Concomitant pleural and disseminated tuberculosis in Aids: Immune response or HIV infection compartmentalization?
چکیده انگلیسی

Although, pleural (PT) and disseminated tuberculosis (DT) have been considered as extreme endpoints of the Th1–Th2 immunological spectrum of the Mycobacterium tuberculosis infection, these conditions can occur together. The presence of PT and DT could be explained by (1) PT as primary condition, with progression of HIV infection possibly leading to dissemination of bacilli located in the pleura; (2) preexisting PT, with reinfection at lower LTCD4+ count explaining the DT form; (3) simultaneous acute PT and DT, considering immune compartmentalization phenomena in pleura. There are several important aspects of the immune response and its compartmentalization in co-infected patients with tuberculosis and HIV. PT and DT should not be always considered as extremes of the immunological response against M. tuberculosis, both diseases together may be explained after the understanding of compartmentalization of immune response. Associations between these entities are not so rare, while they remain incompletely explained. This brief review discusses several points of this contradictory association.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Tropica - Volume 104, Issues 2–3, November–December 2007, Pages 79–83
نویسندگان
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