کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3394717 1221486 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hyperbaric oxygen therapy reduces the size of Leishmania amazonensis-induced soft tissue lesions in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Hyperbaric oxygen therapy reduces the size of Leishmania amazonensis-induced soft tissue lesions in mice
چکیده انگلیسی

In this study we determined whether exposing mice to hyperbaric oxygen (HBO) would alter various disease parameters of a susceptible mouse strain infected with Leishmania amazonensis. BALB/c mice exposed to HBO (100% O2 at a pressure of 2.5 ATA, 1 h before parasite inoculation and subsequently for 20 days) showed significant delay in lesion development and reduction in lesion parasite burdens compared with HBO-unexposed mice. Circulating levels of interferon gamma (IFN-γ) and tumor necrosis factor (TNF-α) were significantly elevated in HBO-exposed as compared to HBO-unexposed mice. Concanavalin A-stimulated lymph nodes cultures from HBO-exposed mice released significantly more IFN-γ and less interleukin 10 (IL-10) than cultures from HBO-unexposed mice, consistent with a skewed Th1 response. These results demonstrate, for the first time, that HBO can play a pathogen control role during leishmaniasis. Further studies are needed to elucidate whether hyperoxia alone or increased atmospheric pressure alone can exert a similar effect.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Tropica - Volume 98, Issue 2, May 2006, Pages 130–136
نویسندگان
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