کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3394783 | 1221490 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
انگل شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi](/preview/png/3394783.png)
چکیده انگلیسی
The rodent malaria parasite Plasmodium chabaudi encodes one food vacuole plasmepsin—the aspartic proteinases important in haemoglobin degradation. A recombinant form of this enzyme was found to cleave a variety of peptide substrates and was susceptible to a selection of naturally occurring and synthetic inhibitors, displaying an inhibition profile distinct from that of aspartic proteinases from other malaria parasites. In addition, inhibitors of HIV proteinase that kill P. chabaudi in vivo were also inhibitors of this new plasmepsin. P. chabaudi is a widely used model for human malaria species and, therefore, the characterisation of this plasmepsin is an important contribution towards understanding its biology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Tropica - Volume 97, Issue 2, February 2006, Pages 212–218
Journal: Acta Tropica - Volume 97, Issue 2, February 2006, Pages 212–218
نویسندگان
Tiago M. Martins, Ana Domingos, Colin Berry, David M. Wyatt,