کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3395676 1221699 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum bactericidal activities of moxifloxacin and levofloxacin against aerobic and anaerobic intra-abdominal pathogens
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Serum bactericidal activities of moxifloxacin and levofloxacin against aerobic and anaerobic intra-abdominal pathogens
چکیده انگلیسی

We studied the serum bactericidal activity (SBA) of moxifloxacin and levofloxacin against common pathogens associated with complicated intra-abdominal infections. Ten healthy volunteers received a single dose of moxifloxacin (400 mg) and levofloxacin (750 mg) and serum samples were collected at 2, 4, 8, 12, and 24 h after the dose of each drug. Bactericidal titers in serum over time were determined for aerobic gram-negative bacilli (Escherichia coli, Klebseilla pneumoniae, and Enterobacter cloacae) and anaerobic bacteria (Bacteroides fragilis, Bacteroides thetaiotaomicron, Prevotella bivia, and Finegoldia magna). Both fluoroquinolones provided rapid (2 h) attainment and prolonged (24 h) SBA (titers ⩾1:8) against each of the aerobic bacilli studied. SBA was observed for at least 12 h against B. fragilis strains with MICs⩽2 μg/ml to moxifloxacin and ⩽4 μg/ml to levofloxacin. Prolonged (12 h) SBA (titers ⩾1:2) was also observed against isolates of B. thetaiotaomicron, P. bivia, and F. magna with moxifloxacin MICs⩽2 μg/ml.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Anaerobe - Volume 14, Issue 1, February 2008, Pages 8–12
نویسندگان
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