کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3395795 1221705 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of Clostridium difficile growth and adhesion to enterocytes by Bifidobacterium supernatants
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Inhibition of Clostridium difficile growth and adhesion to enterocytes by Bifidobacterium supernatants
چکیده انگلیسی

The antimicrobial and anti-adhesive effects of extracellular factors from 27 strains of bifidobacteria isolated from healthy infants were tested against two reference strains of Clostridium difficile (ATCC 9689 and ATCC 43593). All bifidobacterial supernatants at pHs between 5.0 and 4.1 were able to produce strain-dependent growth inhibition of clostridia in the agar-diffusion assay. Six strains of Bifidobacterium produced during growth extracellular factors able to antagonize the adhesion of C. difficile ATCC 9689 and ATCC 43593 to cultured human enterocytes (Caco-2/TC7). Factors responsible for the anti-adhesive effect were thermolabile, active at neutral pH and unaffected by proteolytic cleavage (proteinase K and chymotrypsin).Results of the present paper show the potential of selected bifidobacteria to antagonize key mechanisms involved in the virulence of C. difficile.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Anaerobe - Volume 12, Issue 4, August 2006, Pages 186–193
نویسندگان
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