کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3396729 | 1222186 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prevalence of CXCR4-tropic viruses in clustered transmission chains at the time of primary HIV-1 infection
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Prevalence of CXCR4-tropic viruses in clustered transmission chains at the time of primary HIV-1 infection Prevalence of CXCR4-tropic viruses in clustered transmission chains at the time of primary HIV-1 infection](/preview/png/3396729.png)
چکیده انگلیسی
During 2003–2010, 555 strains isolated from sexually-infected patients at the time of primary HIV-1 infection (PHI) were characterized. Tree topology revealed that 11.7% of PHIs segregated into transmission clusters. CXCR4-usage was identified in 27 strains (4.9%) and was significantly associated with subtype B (p 0.003) and low CD4 cell count (p 0.01). In clustered and unique PHIs, the prevalence of CXCR4-tropic strains was 1.5% and 5.3%, respectively (p 0.35). Our results are in line with the hypothesis of a mucosal bottleneck contributing to the high prevalence of CCR5 variants during PHI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 19, Issue 5, May 2013, Pages E252–E255
Journal: Clinical Microbiology and Infection - Volume 19, Issue 5, May 2013, Pages E252–E255
نویسندگان
P. Frange, L. Meyer, J. Ghosn, C. Deveau, C. Goujard, C. Duvivier, R. Tubiana, C. Rouzioux, M.-L. Chaix,