کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3397631 1222238 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular characterization of resistance to rifampicin in clinical isolates of Neisseria meningitidis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Molecular characterization of resistance to rifampicin in clinical isolates of Neisseria meningitidis
چکیده انگلیسی

Among 3904 meningococcal isolates collected between October 2002 and June 2007 by the French Meningococcal Reference Centre, eight (0.20%) were resistant to rifampicin (Rif-R; MIC >1 mg/L) and 27 (0.69%) were intermediate-resistant to rifampicin (Rif-I; MICs between 0.38 mg/L and 1 mg/L) according to the E-test method. The MICs determined by agar dilution were lower, eliminating the E-test intermediate category. All Rif-R isolates had mutations in the rpoB gene, resulting in substitutions at or near amino acid position 552, which were absent in non-resistant isolates. These data suggest that a rifampicin clinical breakpoint of 1.0 mg/L should be adopted for Neisseria meningitidis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 15, Issue 12, December 2009, Pages 1178–1181
نویسندگان
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