کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3398694 1222311 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular characterisation of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella spp. isolates at a tertiary-care centre in Lebanon
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Molecular characterisation of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella spp. isolates at a tertiary-care centre in Lebanon
چکیده انگلیسی

The prevalence of blaCTX-M, blaTEM and blaSHV genes among extended-spectrum β-lactamase (ESBL)-producing clinical isolates of Escherichia coli (n = 50) and Klebsiella spp. (n = 50) from Lebanon was 96%, 57% and 67%, and 40%, 82% and 84%, respectively. Genotyping revealed that the clonal diversity was unrelated to the presence of bla genes. Sequence analysis of 16 selected isolates identified the blaCTX-M-15, blaTEM-1, blaOXA-1 and six blaSHV genes, as well as the gene encoding the quinolone-modifying enzyme AAC(6′)-Ib-cr. The genes encoding CTX-M-15 and AAC(6′)-Ib-cr were carried on a 90-kb plasmid of the pC15–1a or pCTX-15 type, which transferred both ESBL production and quinolone resistance from donors to transconjugants.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 14, Issue 5, May 2008, Pages 501–504
نویسندگان
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