Antibiotics and the post-genome revolution

The emergence of pathogenic bacteria resistant to multiple antimicrobial agents is turning into a major crisis in human and veterinary medicine. This necessitates a serious re-evaluation of our approaches toward antibacterial drug discovery and use. Concurrent advances in genomics including whole-genome sequencing, genotyping, and gene expression profiling have the potential to transform our basic understanding of antimicrobial pathways and lead to the discovery of novel targets and therapeutics.

► Genomics has a multi-dimensional impact on various aspects of the antibiotic development field.
► Dissecting the pathogenesis phenomenon with potential applications in personalized treatment.
► Optimizing antibiotic biosynthesis process.
► Identification of essential genes and virulence factors as novel targets for therapeutics.
► Understanding antibiotics modes of action and emergence of antibiotic resistance.