کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3399232 | 1222506 | 2011 | 5 صفحه PDF | دانلود رایگان |
A significant fraction of the eukaryotic genome is transcribed into RNAs that do not encode proteins, termed non-coding RNA (ncRNA). One class of ncRNA that is of particular interest is antisense RNAs, which are complementary to protein coding transcripts (mRNAs). In this article, we summarize recent studies using different yeasts that reveal a conserved pattern in which meiotically expressed genes have antisense transcripts in vegetative cells. These antisense transcripts repress the basal transcription of the mRNA during vegetative growth and are diminished as cells enter meiosis. While the mechanism(s) by which these antisense RNAs interfere with production of sense transcripts is not yet understood, the effects appear to be independent of the canonical RNAi machinery.
► Antisense RNAs are common in the yeast transcriptome.
► Antisense RNAs are enriched at meiotically induced genes during mitotic growth.
► The antisense RNAs interfere with basal expression of these genes.
► This is a conserved regulatory strategy for meiotic genes in budding and fission yeasts.
Journal: Current Opinion in Microbiology - Volume 14, Issue 6, December 2011, Pages 655–659