کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3399289 | 1222511 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Control of Salmonella pathogenicity island-2 gene expression Control of Salmonella pathogenicity island-2 gene expression](/preview/png/3399289.png)
The Salmonella Pathogenicity Island-2 (i.e. SPI-2) encodes a unique type III secretion system that delivers effector proteins from the Salmonella-containing vacuole (SCV) into the host cell. The SPI-2 locus also encodes translocated effectors as well as a two-component system – termed SpiR/SsrB – that is essential for the expression of SPI-2 genes. Transcription of the horizontally acquired SPI-2 genes requires the ancestral nucleoid-associated proteins (i.e. NAPs) IHF and Fis, the regulatory protein SlyA, and the two-component systems PhoP/PhoQ and OmpR/EnvZ, as well as the DNA binding protein HilD encoded in a different pathogenicity island. Some of these positive SPI-2 regulators act to antagonize the robust silencing promoted by the NAPs H-NS, Hha, and YdgT.
Journal: Current Opinion in Microbiology - Volume 12, Issue 2, April 2009, Pages 199–204