کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3399346 | 1222516 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Conservation and divergence of centromere specification in yeast
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Centromeres are specialized structures on eukaryotic chromosomes that couple chromosome movements to spindle microtubule movements and allow accurate chromosome segregation during cell division. In spite of these vital functions, recent evidence strongly suggests that epigenetic regulation rather than the primary DNA sequence of the centromere plays a dominant role in the specification of centromeres. The key determinant of centromere identity is the centromere-specific histone H3 variant CENP-A (also known as CenH3). This review highlights exciting new findings examining the mechanism of centromere specification in distinct yeast species, which provides insights into CENP-A nucleosome assembly and establishment of centromere identity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Microbiology - Volume 12, Issue 6, December 2009, Pages 616–622
Journal: Current Opinion in Microbiology - Volume 12, Issue 6, December 2009, Pages 616–622
نویسندگان
Kojiro Ishii,